Synthesis of Novel Heterocyclic N-Oxide Glycosides: Glycosylation of Myxin Analogs
نویسندگان
چکیده
Phenazines and heterocyclic N-oxides have proven to be interesting classes of antitumoral as well as antibiotic agents . The natural product myxin (1-hydroxy-6-methoxyphenazineN5, N10-dioxide) which belongs to both of these unique classes of molecules, has been found to cause bio-reductively activated, radical-mediated DNA strand cleavage via a de-oxygenative mechanism, making it a potential antitumoral as well as anti-bactierial candidate. In order to investigate as well as improve the bioactive properties of myxin, the following study was designed to synthesize glycosylated myxin analogs. A small catalog of these compounds were synthesized, some of them exhibiting comparable biological activity to that of myxin. INDEX WORDS: Myxin, Phenazines, Heterocylcic N-oxides, Glycosylation, Carbohydrates, Bioreductive SYNTHESIS OF NOVEL HETEROCYCLIC N-OXIDE GLYCOSIDES: GLYCOSYLATION OF MYXIN ANALOGS
منابع مشابه
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